01 - Pat catfish fillets completely dry using paper towels. Generously season both sides with salt, black pepper, and Cajun seasoning, pressing gently to adhere.
02 - In a shallow bowl, whisk together eggs and buttermilk until fully combined and smooth.
03 - In a separate wide bowl, combine cornmeal, all-purpose flour, paprika, garlic powder, and onion powder. Mix thoroughly to distribute spices evenly.
04 - Working one fillet at a time, dip fish into egg-buttermilk mixture, allowing excess to drip off. Dredge generously in cornmeal breading, pressing lightly to ensure coating adheres completely.
05 - Pour vegetable oil into heavy skillet or deep fryer to depth of at least 2 inches. Heat to 350°F, monitoring with thermometer for accuracy.
06 - Fry fillets in batches without overcrowding, cooking 3 to 4 minutes per side until golden brown and cooked through. Maintain oil temperature throughout frying.
07 - Transfer fried catfish to wire rack or paper towels to drain excess oil. Serve immediately with lemon wedges and tartar sauce.